If instead he ends up with Dominka, that's not bad either since she's smart enough, and morally ambiguous enough, to be a compatible partner to House.
Really agree with this. House has never had good chemistry with his love interests -- Cameron and Cuddy -- because their whole position seemed to be 'Omigod, I love him, I can change him, I can save him.' (I say this as someone who really liked Cameron, but never when she was in House-crush mode).
On the contrary, House has had great 'bromantic' chemistry with Wilson and Alvy because those characters continued to be sarcastic, imperfect and real even when they were around House. House only genuinely smiles and laughs around Wilson -- watch the scene again where House and Wilson are joking around about 'balls' in the cooking class in 'Epic Fail,' (6.2). For a second or two, it's like you're watching HL and RSL being themselves in outtakes.
I'm not shipping Wilson; my point is that I could never imagine House hanging out with Cameron or Cuddy (or Stacy, for that matter) like a friend. Their sincerity (at least in relation to him) would bore him sick. The 'fun' or date scenes with Cuddy in Season 7 never rang true to me. On the contrary, he seems to have a real simpatico with 'insincere' women, however brief their screen time. I'm thinking of the witty 'half-Jewish' job applicant in Season One, Thirteen (especially in 'The Dig'), the prostitute who helps him scam Kutner and Taub in Season Five, the prostitute who does the 'shot by an arrow' prank with him in Season Seven, and now, Dominika. I'd like to see the series end with him carrying on a low-key, imperfect, real-world thing with her, one that isn't based on the unrealistic premise of One True Love that'll heal his character flaws and leg pain both.