Actually, rewatching this season, River's timeline is starting to clear up, at least from the moment she regenerated into Alex Kingston's body. Her childhood (until she somehow finds her way to Leadworth) is pretty much a mess, and I am not sure we will revisit it to make it clear. (Actually I am pretty sure we won't).
1. In Let's Kill Hitler we are shown a lot about her life as Mels, we watch her die, regenerate, fulfill her programming to kill the Doctor, than to revive the Doctor using up her remaining regenerations, thus losing this ability.
2. Altough this happens in 1938, the Doctor takes her to the best hospital, which I think is in the 52nd century. When she get's well, she starts University to be an Archeologist thus she try to find the Doctor. This happens in 5122.
3. She finishes University and gets the title doctor in this episode, which is in her timeline is probably 7-8 years from the start. So it is around 5129 or 5130. Since she already "killed" the Doctor once, the programming in her stopped, and she is pretty much in love with the Doctor altough they haven't met since Let's Kill Hitler. But Madame Kovarian finds her here and use her to kill the Doctor again. Since I think the astronaut suit can move on its own, it doesn't need River to be in it, but I speculate Madame Kovarian enjoys to put her in as a punishment to go against her brainwashing earlier.
4. She "kills" the Doctor again, and this time, since it's not part of her programming, she remembers it later. She knows that the Doctor lives, but willing to go into prison for keeping the secret. She spends at least 15 years in prison, but maybe more. (At the beginning of The Big Bang it is 5145). Of course she is spends only her days in the prison, in the nights she's escaping whatever she likes - most of the time with the Doctor.
5. I don't think we will see their trips (altough I would love to), but we can assume there are a lot of them. Some of them shorter trips, like when she is taken to the Stevie Wonder thing on her birthday, some are longer, but after every trip she goes back to her cell. We don't know if she goes out with pre-TWoRS Doctor or with the post-TWoRS Doctor, probably with both, in random order. At this time her timeline is not really the reverse of the Doctor's, just out of order. In the "official River Song Timeline" she says that from the events in AGMGTW she feels their timeline is going to the reverse order, she knows more about him, he knows less about her.
6. When she is released from the prison she goes back to the University where she becomes Professor. Thanks to her trips to the various worlds in any given time-period, she has to be the best Archeologist Professor since Indiana Jones.
7. Than she dies/live forever in the computer in the 51st century. It is earlier than her normal timeline and I don't know if it was a continuity error, sinc it would have been simpler if all this is happening in her own time-frame. But I don't think it is important in her story.
And this is it, except for one thing:
+1. It is pure speculation, but I think, the Doctor who gives her the sonic screwdriver before she goes to the Library, it is the Doctor who is preparing for his death, and arranging things for that reason. So it is between God Complex and Closing Time. It is just something he would do, when thinking he would really die.
Edited by Ysu, Nov 10, 2011 @ 12:08 PM.