I was trying to remember whether anyone in any of the crews, or any of their their stated ancestors or relatives was from London - and as far as I remember none of them were - the British characters were all from other areas or we never knew exactly where in the UK they grew up. In fact the only possible Star Trek connection with the city I can think of was the London Kings baseball team in DS9.
So it won't make a difference to the continuity if it gets totally blown to pieces, and it's interesting to see something new. I like that the London Eye seems to still be up.
It possibly also implies that the Cumberbatch may not be bothering with faking an accent. I'm pretty sure Gary Mitchell was American last time, although his parents could easily have moved to the UK. As for Khan... I think this makes that pretty unlikely. A well-known, iconic character like that would have to have some back-story related to this, and what connection did he have with London?
Edited by Lebanna, Dec 3, 2012 @ 7:06 PM.